Prenatal Stress, Glucocorticoids, and Developmental Programming of the Stress Response
نویسندگان
چکیده
منابع مشابه
Prenatal Stress, Glucocorticoids and the Programming of Adult Disease
Numerous clinical studies associate an adverse prenatal environment with the development of cardio-metabolic disorders and neuroendocrine dysfunction, as well as an increased risk of psychiatric diseases in later life. Experimentally, prenatal exposure to stress or excess glucocorticoids in a variety of animal models can malprogram offspring physiology, resulting in a reduction in birth weight ...
متن کاملFetal programming of hypothalamo-pituitary-adrenal function: prenatal stress and glucocorticoids.
Prenatal stress (PS) and maternal exposure to exogenous glucocorticoids can lead to permanent modification of hypothalamo-pituitary-adrenal (HPA) function and stress-related behaviour. Both of these manipulations lead to increased fetal exposure to glucocorticoids. Glucocorticoids are essential for many aspects of normal brain development, but exposure of the fetal brain to an excess of glucoco...
متن کاملMaternal glucocorticoids and prenatal programming of hypertension.
Maternal glucocorticoids have been postulated to play an important role in prenatal programming for adult hypertension in the offspring. However, we have shown previously that offspring hypertension caused by maternal dexamethasone subcutaneous administration at 100 microg x kg(-1) x day(-1) can be accounted for by the corresponding reduction in food intake that these mothers experience. The pr...
متن کاملPrenatal treatment with glucocorticoids sensitizes the hpa axis response to stress among full-term infants.
The objective of this study was to determine the consequences for HPA axis functioning among healthy full-term newborns of prenatal treatment with the synthetic glucocorticoid (GC), betamethasone, which is the routine treatment for threatened preterm delivery. Ninety full-term infants were recruited into two study groups (30 betamethasone treated; 60 comparison group matched for GA at birth and...
متن کاملPrenatal stress and the programming of the HPA axis.
There are several independent prospective studies showing that a wide variety of forms of prenatal stress can have long-term effects on the behavioural and cognitive outcome for the child. Animal studies have shown that prenatal stress, as well as affecting behaviour, can also reprogram the function of the HPA axis in the offspring. However, the effects on the HPA axis are very variable dependi...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 2017
ISSN: 1945-7170
DOI: 10.1210/en.2017-00896